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Article

Conventional PKCs regulate the temporal pattern of Ca2+ oscillations at fertilization in mouse eggs

29 Mar 2004

Abstract excerpt

In mammalian eggs, sperm-induced Ca2+ oscillations at fertilization are the primary trigger for egg activation and initiation of embryonic development. Identifying the downstream effectors that decode this unique Ca2+ signal is essential to understand how the transition from egg to embryo is coordinated. Here, we investigated whether conventional PKCs (cPKCs) can decode Ca2+ oscillations at fertilization. By...

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PMID: 15051735
DOI: 10.1083/jcb.200311023

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