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Article

Novel signalling mechanism and clinical applications of sperm-specific PLCζ

26 May 2015

Abstract excerpt

Egg activation is the first step of embryonic development and in mammals is triggered by a series of cytoplasmic calcium (Ca2+) oscillations. Sperm-egg fusion initiates these Ca2+ oscillations by introducing a sperm-specific protein factor into the egg cytoplasm. Substantial evidence indicates that this protein is a sperm-specific phospholipase C (PLC), termed PLC-zeta (PLCζ). PLCζ stimulates cytoplasmic Ca2+...

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PMID: 26009178
DOI: 10.1042/bst20140291

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