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Article

Sperm PLCζ: From structure to Ca<sup>2+</sup> oscillations, egg activation and therapeutic potential

21 Oct 2013

Abstract excerpt

Significant evidence now supports the assertion that cytosolic calcium oscillations during fertilization in mammalian eggs are mediated by a testis-specific phospholipase C (PLC), termed PLC-zeta (PLCζ) that is released into the egg following gamete fusion. Herein, we describe the current paradigm of PLCζ in this fundamental biological process, summarizing recent important advances in our knowledge of the...

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Identifiers

PMID: 24157362
DOI: 10.1016/j.febslet.2013.10.008

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