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Article

PLCζ: a sperm-specific trigger of Ca2+ oscillations in eggs and embryo development

1 Aug 2002

Abstract excerpt

Upon fertilisation by sperm, mammalian eggs are activated by a series of intracellular Ca(2+) oscillations that are essential for embryo development. The mechanism by which sperm induces this complex signalling phenomenon is unknown. One proposal is that the sperm introduces an exclusive cytosolic factor into the egg that elicits serial Ca(2+) release. The 'sperm factor' hypothesis has not been ratified because a...

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Identifiers

PMID: 12117804
DOI: 10.1242/dev.129.15.3533

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