Article
Heterogeneous distribution of Plasmodium falciparum drug resistance haplotypes in subsets of the host population.
Malaria journal - 6 May 2008
Schoepflin Sonja, Marfurt Jutta, Goroti Mary, Baisor Moses, Mueller Ivo, Felger Ingrid
Abstract excerpt
BACKGROUND: The emergence of drug resistance is a major problem in malaria control. For mathematical modelling of the transmission and spread of drug resistance the determinant parameters need to be identified and measured. The underlying hypothesis is that mutations associated with drug resistance incur fitness costs to the parasite in absence of drug pressure. The distribution of drug resistance haplotypes in...
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