Plasmodium falciparum drug resistance phenotype as assessed by patient antimalarial drug levels and its association with pfmdr1 polymorphisms.

doi:10.1093/infdis/jis747

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Article

Plasmodium falciparum drug resistance phenotype as assessed by patient antimalarial drug levels and its association with pfmdr1 polymorphisms.

The Journal of infectious diseases - 1 Mar 2013

Malmberg Maja, Ferreira Pedro E, Tarning Joel, Ursing Johan, Ngasala Billy, Björkman Anders, Mårtensson Andreas, Gil José P

Abstract excerpt

BACKGROUND: Multidrug-resistant Plasmodium falciparum is a major threat to global malaria control. Parasites develop resistance by gradually acquiring genetic polymorphisms that decrease drug susceptibility. The aim of this study was to investigate the extent to which parasites with different genetic characteristics are able to withstand individual drug blood concentrations. METHODS: We analyzed 2 clinical trials...

Topics

Antimalarials
Artemether, Lumefantrine Drug Combination
Artemisinins
Child, Preschool
Clinical Trials as Topic
Drug Combinations
Drug Resistance
Ethanolamines
Female
Fluorenes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Infant

Male

Multidrug Resistance-Associated Proteins

Plasmodium falciparum

Polymorphism, Single Nucleotide

Secondary Prevention

Source

Open in PubMed Open full text

Identifiers

PMID: 23225895
DOI: 10.1093/infdis/jis747
PMCID: PMC3563306

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-23225895-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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