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Article

Impact of changing drug treatment and malaria endemicity on the heritability of malaria phenotypes in a longitudinal family-based cohort study.

PloS one - 1 Jan 2011

Loucoubar Cheikh, Goncalves Bronner, Tall Adama, Sokhna Cheikh, Trape Jean-François, Diène Sarr Fatoumata, Faye Joseph, Badiane Abdoulaye, Ly Alioune Badara, Diop Aliou, Bar-Hen Avner, Bureau Jean-François, Sakuntabhai Anavaj, Paul Richard

Abstract excerpt

Despite considerable success of genome wide association (GWA) studies in identifying causal variants for many human diseases, their success in unraveling the genetic basis to complex diseases has been more mitigated. Pathogen population structure may impact upon the infectious phenotype, especially with the intense short-term selective pressure that drug treatment exerts on pathogens. Rigorous analysis that...

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Identifiers

PMID: 22073159
DOI: 10.1371/journal.pone.0026364
PMCID: PMC3207815

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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