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Article

Frequency distribution of antimalarial drug-resistant alleles among isolates of Plasmodium falciparum in Bangui, Central African Republic.

The American journal of tropical medicine and hygiene - 1 Feb 2006

Menard Didier, Djalle Djibrine, Yapou Ferdinand, Manirakiza Alexandre, Talarmin Antoine

Abstract excerpt

We determined the baseline frequency distribution of mutant alleles of genes associated with resistance to chloroquine and sulfadoxine-pyrimethamine in Plasmodium falciparum isolates in Bangui, Central African Republic. Mutant alleles of the P. falciparum chloroquine resistance transporter (pfcrt) gene were found in all samples and the frequency of the deduced CIET pfcrt haplotype was high (45%). The most common...

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PMID: 16474071

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