Article
Frequency distribution of antimalarial drug-resistant alleles among isolates of Plasmodium falciparum in Bangui, Central African Republic.
The American journal of tropical medicine and hygiene - 1 Feb 2006
Menard Didier, Djalle Djibrine, Yapou Ferdinand, Manirakiza Alexandre, Talarmin Antoine
Abstract excerpt
We determined the baseline frequency distribution of mutant alleles of genes associated with resistance to chloroquine and sulfadoxine-pyrimethamine in Plasmodium falciparum isolates in Bangui, Central African Republic. Mutant alleles of the P. falciparum chloroquine resistance transporter (pfcrt...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Animals
- Antimalarials
- Central African Republic
- Chloroquine
- Drug Combinations
- Drug Resistance, Multiple
- Gene Frequency
- Humans
- Malaria, Falciparum
- Membrane Proteins
- Membrane Transport Proteins
- Mutation
- Plasmodium falciparum
- Protozoan Proteins
- Pyrimethamine
- Sulfadoxine