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Article

A deep sequencing tool for partitioning clearance rates following antimalarial treatment in polyclonal infections

1 Jan 2016

Abstract excerpt

BACKGROUND AND OBJECTIVES: Current tools struggle to detect drug-resistant malaria parasites when infections contain multiple parasite clones, which is the norm in high transmission settings in Africa. Our aim was to develop and apply an approach for detecting resistance that overcomes the challenges of polyclonal infections without requiring a genetic marker for resistance. METHODOLOGY: Clinical samples from...

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PMID: 26817485
DOI: 10.1093/emph/eov036

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