Article
Genetic diversity of next generation antimalarial targets: A baseline for drug resistance surveillance programmes.
International journal for parasitology. Drugs and drug resistance - 1 Aug 2017
Gomes Ana Rita, Ravenhall Matt, Benavente Ernest Diez, Talman Arthur, Sutherland Colin, Roper Cally, Clark Taane G, Campino Susana
Abstract excerpt
Drug resistance is a recurrent problem in the fight against malaria. Genetic and epidemiological surveillance of antimalarial resistant parasite alleles is crucial to guide drug therapies and clinical management. New antimalarial compounds are currently at various stages of clinical trials and regulatory evaluation. Using ∼2000 Plasmodium falciparum genome sequences, we investigated the genetic diversity of...
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