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Article

Changes in malaria parasite drug resistance in an endemic population over a 25-year period with resulting genomic evidence of selection.

The Journal of infectious diseases - 1 Apr 2014

Nwakanma Davis C, Duffy Craig W, Amambua-Ngwa Alfred, Oriero Eniyou C, Bojang Kalifa A, Pinder Margaret, Drakeley Chris J, Sutherland Colin J, Milligan Paul J, Macinnis Bronwyn, Kwiatkowski Dominic P, Clark Taane G, Greenwood Brian M, Conway David J

Abstract excerpt

BACKGROUND: Analysis of genome-wide polymorphism in many organisms has potential to identify genes under recent selection. However, data on historical allele frequency changes are rarely available for direct confirmation. METHODS: We genotyped single nucleotide polymorphisms (SNPs) in 4 Plasmodium falciparum drug resistance genes in 668 archived parasite-positive blood samples of a Gambian population between 1984...

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Identifiers

PMID: 24265439
DOI: 10.1093/infdis/jit618
PMCID: PMC3952670

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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