Article
Ahead of the curve: next generation estimators of drug resistance in malaria infections.
Trends in parasitology - 1 Jul 2013
Mideo Nicole, Kennedy David A, Carlton Jane M, Bailey Jeffrey A, Juliano Jonathan J, Read Andrew F
Abstract excerpt
Drug resistance is a major obstacle to controlling infectious diseases. A key challenge is detecting the early signs of drug resistance when little is known about its genetic basis. Focusing on malaria parasites, we propose a way to do this. Newly developing or low level resistance at low frequency in patients can be detected through a phenotypic signature: individual parasite variants clearing more slowly...
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