In vitro genetic analysis of the hinge region between helical elements P5-P4-P6 and P7-P3-P8 in the sunY group I self-splicing intron.

doi:10.1016/s0022-2836(05)80022-1

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Article

In vitro genetic analysis of the hinge region between helical elements P5-P4-P6 and P7-P3-P8 in the sunY group I self-splicing intron.

Journal of molecular biology - 7 Jan 1994

Green R, Szostak J W

Abstract excerpt

Modeling of the group I intron RNA suggests that its catalytic core is primarily composed of two extended structural elements (stacked helices P5-P4-P6 and P7-P3-P8) whose relative orientation is partially determined by base-triple interactions between paired regions P4 and P6, and single-stranded joining regions J6/7 and J3/4, respectively. In vitro genetic selection was used to isolate functional sequence...

Topics

Animals
Base Composition
Base Sequence
DNA Primers
Exons
Genetic Variation
Hydrogen Bonding
Introns
Models, Molecular
Molecular Sequence Data
Molecular Structure

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutagenesis

Nucleic Acid Conformation

Oligodeoxyribonucleotides

RNA

RNA Splicing

RNA, Catalytic

Tetrahymena

Source

Open in PubMed

Identifiers

PMID: 7507168
DOI: 10.1016/s0022-2836(05)80022-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7507168-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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In vitro genetic analysis of the hinge region between helical elements P5-P4-P6 and P7-P3-P8 in the sunY group I self-splicing intron.PMID 7507168Read ↗

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