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Article

Protein kinase C beta overexpression induces fibrotic effects in human proximal tubular epithelial cells.

The international journal of biochemistry & cell biology - 1 Jan 2008

Slattery Craig, Ryan Michael P, McMorrow Tara

Abstract excerpt

Cyclosporine A (CsA) significantly improves the success of organ transplantation, however renal fibrosis, characterised by severe tubulointerstitial fibrosis is a complication of CsA therapy. Previously we have reported the involvement of PKC-beta isoforms in a model of CsA-induced tubulointerstitial fibrosis and we have now further elucidated this role. Treatment of human proximal tubular epithelial cells with...

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Identifiers

PMID: 18440851
DOI: 10.1016/j.biocel.2008.03.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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