Article
Epithelial phenotypic changes detect cyclosporine in vivo nephrotoxicity at a reversible stage.
Transplantation - 15 Nov 2011
Galichon Pierre, Vittoz Nathalie, Xu-Dubois Yi-Chun, Cornaire Emilie, Vandermeersch Sophie, Mesnard Laurent, Hertig Alexandre, Rondeau Eric
Abstract excerpt
BACKGROUND: A widely used immunosuppressant, cyclosporine A (CsA), conveys long-term nephrotoxicity in some patients. However, no specific marker is presently available. In both native and transplanted human kidneys, epithelial phenotypic changes (EPCs) suggestive of epithelial to mesenchymal transition (EMT) are expressed in various diseases and are prognostic with respect to progression of interstitial...
Topics
- Acute Kidney Injury
- Angiotensin II
- Animals
- Biomarkers
- Collagen Type III
- Cyclosporine
- Epithelial Cells
- Epithelial-Mesenchymal Transition
- HSP47 Heat-Shock Proteins
- Immunosuppressive Agents
- Kidney
- Male
- Models, Animal