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Article

Epithelial phenotypic changes detect cyclosporine in vivo nephrotoxicity at a reversible stage.

Transplantation - 15 Nov 2011

Galichon Pierre, Vittoz Nathalie, Xu-Dubois Yi-Chun, Cornaire Emilie, Vandermeersch Sophie, Mesnard Laurent, Hertig Alexandre, Rondeau Eric

Abstract excerpt

BACKGROUND: A widely used immunosuppressant, cyclosporine A (CsA), conveys long-term nephrotoxicity in some patients. However, no specific marker is presently available. In both native and transplanted human kidneys, epithelial phenotypic changes (EPCs) suggestive of epithelial to mesenchymal transition (EMT) are expressed in various diseases and are prognostic with respect to progression of interstitial...

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PMID: 21909056
DOI: 10.1097/TP.0b013e31822fa495

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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