Article
Calcineurin inhibitor effects on growth and phenotype of human airway epithelial cells in vitro.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons - 1 Nov 2005
Neuringer Isabel P, Sloan Jessica, Budd Steven, Chalermskulrat Worakij, Park Richard C W, Stonebraker Jaclyn R, O'Neal Wanda K, Aris Robert M, Randell Scott H
Abstract excerpt
Calcineurin inhibitors (CIs) cyclosporin and tacrolimus form the basis for immunosuppression in lung transplantation, yet also exert biological effects on nonlymphoid tissue. With the advent of inhaled cyclosporin, we hypothesize that the airway epithelium is also subject to CI effects at high doses. The aim of this study was to identify human tracheobronchial epithelial cell (hTBEC) calcineurin gene expression...
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