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Article

Electroporation-mediated HGF gene transfer ameliorated cyclosporine nephrotoxicity.

Kidney international - 1 Jun 2004

Mizui Masayuki, Isaka Yoshitaka, Takabatake Yoshitsugu, Mizuno Sinya, Nakamura Toshikazu, Ito Takahito, Imai Enyu, Hori Masatsugu

Abstract excerpt

BACKGROUND: The clinical utility of cyclosporine A (CsA) has been limited by its nephrotoxicity, which is characterized by tubular atrophy, interstitial fibrosis, and progressive renal impairment. Hepatocyte growth factor (HGF) has been reported to protect and salvage from renal injury as a renotropic and antifibrotic factor. Here, we investigated protective effects of HGF gene therapy on rat CsA-induced...

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Source

Identifiers

PMID: 15149317
DOI: 10.1111/j.1523-1755.2004.00625.x

Genes

HGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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