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Article

Protein kinase C-epsilon mediates bradykinin-induced cyclooxygenase-2 expression in human airway smooth muscle cells.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Sept 2002

Pang Linhua, Nie Mei, Corbett Lisa, Donnelly Richard, Gray Samuel, Knox Alan J

Abstract excerpt

We previously reported that proinflammatory mediator bradykinin (BK) induces cyclooxygenase (COX)-2 expression in human airway smooth muscle (HASM), but the mechanism is unknown in any biological system. Here, we studied the role of specific protein kinase C (PKC) isozyme(s) in COX-2 expression. Among the eight PKC isozymes present in HASM cells, the Ca2+-independent PKC-delta and -epsilon and the Ca2+-dependent...

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Identifiers

PMID: 12205039
DOI: 10.1096/fj.02-0169fje

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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