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Article

Influence of the catechol-O-methyltransferase val158met genotype on amygdala and prefrontal cortex emotional processing in panic disorder.

Psychiatry research - 30 May 2008

Domschke Katharina, Ohrmann Patricia, Braun Miriam, Suslow Thomas, Bauer Jochen, Hohoff Christa, Kersting Anette, Engelien Almut, Arolt Volker, Heindel Walter, Deckert Jürgen, Kugel Harald

Abstract excerpt

Panic disorder is an anxiety disorder with an estimated heritability of up to 48%. The functional val158met polymorphism in the catechol-O-methyltransferase (COMT) gene has been found to be associated with panic disorder and to influence limbic and prefrontal brain activation in response to unpleasant stimuli. In the present study, neuronal activation following emotional stimulation was used as an endophenotype...

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Source

Identifiers

PMID: 18440204
DOI: 10.1016/j.pscychresns.2007.04.016

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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