The effects of gender and catechol O-methyltransferase (COMT) Val108/158Met polymorphism on emotion regulation in velo-cardio-facial syndrome (22q11.2 deletion syndrome): An fMRI study.

doi:10.1016/j.neuroimage.2010.01.094

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Article

The effects of gender and catechol O-methyltransferase (COMT) Val108/158Met polymorphism on emotion regulation in velo-cardio-facial syndrome (22q11.2 deletion syndrome): An fMRI study.

NeuroImage - 15 Nov 2010

Coman Ioana L, Gnirke Matthew H, Middleton Frank A, Antshel Kevin M, Fremont Wanda, Higgins Anne Marie, Shprintzen Robert J, Kates Wendy R

Abstract excerpt

Velo-cardio-facial syndrome (VCFS) is caused by a micro-deletion of over 40 genes at the q11.2 locus of chromosome 22 and is a risk factor for the development of schizophrenia and other psychiatric disorders. COMT, one of the genes located in the deleted region, has been considered as a major candidate gene for genetic susceptibility in psychiatric diseases. Its functional polymorphism Val108/158Met has been...

Topics

Adolescent
Brain Mapping
Catechol O-Methyltransferase
Child
DiGeorge Syndrome
Emotions
Female
Genotype
Humans
Image Interpretation, Computer-Assisted

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Magnetic Resonance Imaging

Male

Mental Disorders

Polymerase Chain Reaction

Polymorphism, Single Nucleotide

Sex Factors

Young Adult

Source

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Identifiers

PMID: 20123031
DOI: 10.1016/j.neuroimage.2010.01.094
PMCID: PMC2906653

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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