Article
The impact of the Val158Met catechol-O-methyltransferase genotype on neural correlates of sad facial affect processing in patients with bipolar disorder and their relatives.
Psychological medicine - 1 Apr 2011
Lelli-Chiesa G, Kempton M J, Jogia J, Tatarelli R, Girardi P, Powell J, Collier D A, Frangou S
Abstract excerpt
BACKGROUND: The Met allele of the catechol-O-methyltransferase (COMT) valine-to-methionine (Val158Met) polymorphism is known to affect dopamine-dependent affective regulation within amygdala-prefrontal cortical (PFC) networks. It is also thought to increase the risk of a number of disorders characterized by affective morbidity including bipolar disorder (BD), major depressive disorder (MDD) and anxiety disorders....
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