Article
Association of the functional -1019C/G 5-HT1A polymorphism with prefrontal cortex and amygdala activation measured with 3 T fMRI in panic disorder.
The international journal of neuropsychopharmacology - 1 Jun 2006
Domschke Katharina, Braun Miriam, Ohrmann Patricia, Suslow Thomas, Kugel Harald, Bauer Jochen, Hohoff Christa, Kersting Anette, Engelien Almut, Arolt Volker, Heindel Walter, Deckert Jürgen
Abstract excerpt
Serotonergic genes have been implicated in the pathogenesis of panic disorder and amygdala function in response to fearful stimuli. Regional brain activation on visual presentation of emotional facial stimuli was investigated in 20 patients with panic disorder by means of fMRI at 3 T. All patients were genotyped for the functional -1019C/G 5-HT1A and 5-HTTLPR polymorphisms. In patients homozygous for the 5-HT1A...
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