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Article

Molecular mechanism of drug-dependent ribosome stalling.

Molecular cell - 25 Apr 2008

Vazquez-Laslop Nora, Thum Celine, Mankin Alexander S

Abstract excerpt

Inducible expression of the erm erythromycin resistance genes relies on drug-dependent ribosome stalling. The molecular mechanisms underlying stalling are unknown. We used a cell-free translation system to elucidate the contribution of the nascent peptide, the drug, and the ribosome toward formation of the stalled complex during translation of the ermC leader cistron. Toe-printing mapping, selective amino acid...

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PMID: 18439898
DOI: 10.1016/j.molcel.2008.02.026

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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