The Expression of Antibiotic Resistance Methyltransferase Correlates with mRNA Stability Independently of Ribosome Stalling.

doi:10.1128/AAC.01806-16

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Article

The Expression of Antibiotic Resistance Methyltransferase Correlates with mRNA Stability Independently of Ribosome Stalling.

Antimicrobial agents and chemotherapy - 1 Dec 2016

Dzyubak Ekaterina, Yap M N

Abstract excerpt

Members of the Erm methyltransferase family modify 23S rRNA of the bacterial ribosome and render cross-resistance to macrolides and multiple distantly related antibiotics. Previous studies have shown that the expression of erm is activated when a macrolide-bound ribosome stalls the translation of the leader peptide preceding the cotranscribed erm Ribosome stalling is thought to destabilize the inhibitory...

Topics

Anti-Bacterial Agents
Bacterial Proteins
Drug Resistance, Bacterial
Erythromycin
Escherichia coli
Gene Expression Regulation, Bacterial
Methyltransferases
Mutation
Operon
Protein Sorting Signals
RNA Stability
Ribosomes
Staphylococcus aureus

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Identifiers

PMID: 27645242
DOI: 10.1128/AAC.01806-16
PMCID: PMC5118997

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