Article

Structural basis for the context-specific action of classic peptidyl transferase inhibitors

2021-06-18

Abstract excerpt

<h4>ABSTRACT</h4> Ribosome-targeting antibiotics serve both as powerful antimicrobials and as tools for studying the ribosome. The ribosomal catalytic site, the peptidyl transferase center (PTC), is targeted by a large number of various drugs. The classical and best-studied PTC-acting antibiotic chloramphenicol, as well as the newest clinically significant linezolid, were considered indiscriminate inhibitors of e...

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Literature Corpus work: 6fa4e206-2a31-5374-b692-aa81aec0487f
DOI: 10.1101/2021.06.17.448903

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