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Article

Context-specific action of macrolide antibiotics on the eukaryotic ribosome.

Nature communications - 14 May 2021

Svetlov Maxim S, Koller Timm O, Meydan Sezen, Shankar Vaishnavi, Klepacki Dorota, Polacek Norbert, Guydosh Nicholas R, Vázquez-Laslop Nora, Wilson Daniel N, Mankin Alexander S

Abstract excerpt

Macrolide antibiotics bind in the nascent peptide exit tunnel of the bacterial ribosome and prevent polymerization of specific amino acid sequences, selectively inhibiting translation of a subset of proteins. Because preventing translation of individual proteins could be beneficial for the treatment of human diseases, we asked whether macrolides, if bound to the eukaryotic ribosome, would retain their context-...

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Share to Cryoelectron Microscopy
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33990576
DOI: 10.1038/s41467-021-23068-1
PMCID: PMC8121947

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