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Article

Effect of ermC leader region mutations on induced mRNA stability.

Journal of bacteriology - 1 Jun 1991

Hue K K, Bechhofer D H

Abstract excerpt

Induction of translation of the ermC gene product in Bacillus subtilis occurs upon exposure to erythromycin and is a result of ribosome stalling in the ermC leader peptide coding sequence. Another result of ribosome stalling is stabilization of ermC mRNA. The effect of leader RNA secondary structure, methylase translation, and leader peptide translation on induced ermC mRNA stability was examined by constructing...

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Identifiers

PMID: 1711026
DOI: 10.1128/jb.173.12.3732-3740.1991
PMCID: PMC208002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Effect of ermC leader region mutations on induced mRNA stability.PMID 1711026Read ↗

The Expression of Antibiotic Resistance Methyltransferase Correlates with mRNA Stability Independently of Ribosome Stalling.Semantic proximity Read ↗

Molecular mechanism of drug-dependent ribosome stalling.Semantic proximity Read ↗

Identification of cis-acting sequences required for translational autoregulation of the ermC methylase.Semantic proximity Read ↗

Transcriptional attenuation control of ermK, a macrolide-lincosamide-streptogramin B resistance determinant from Bacillus licheniformis.Semantic proximity Read ↗

Effect of translational signals on mRNA decay in Bacillus subtilis.Semantic proximity Read ↗

Effect of 5'-proximal elements on decay of a model mRNA in Bacillus subtilis.Semantic proximity Read ↗

The ermC leader peptide: amino acid alterations leading to differential efficiency of induction by macrolide-lincosamide-streptogramin B antibiotics.Semantic proximity Read ↗

Nascent SecM chain interacts with outer ribosomal surface to stabilize translation arrest.Semantic proximity Read ↗

Alanine-scanning mutagenesis of the predicted rRNA-binding domain of ErmC' redefines the substrate-binding site and suggests a model for protein-RNA interactions.Semantic proximity Read ↗

Effects on translation pausing of alterations in protein and RNA components of the ribosome exit tunnel.Semantic proximity Read ↗

Translation arrest requires two-way communication between a nascent polypeptide and the ribosome.Semantic proximity Read ↗

Identification of a hyperactive variant of the SecM motif involved in ribosomal arrest.Semantic proximity Read ↗

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