Article

Deep conservation of ribosome stall sites across RNA processing genes

2020-09-18

Abstract excerpt

The rate of translation can vary considerably depending on the mRNA template. During the elongation phase the ribosome can transiently pause or permanently stall. A pause can provide the nascent protein with the required time to fold or be transported, while stalling can serve as quality control and trigger degradation of aberrant mRNA and peptide. Ribosome profiling has allowed for the genome-wide detection of su...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6c4d3aa7-eb96-54a6-86a5-b562a42b1138
DOI: 10.1101/2020.09.17.301754

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Deep conservation of ribosome stall sites across RNA processing genesDOI 10.1101/2020.09.17.301754Read

Genome-wide Survey of Ribosome CollisionSemantic proximity Read

Sucrose-mediated translational stalling involves a conserved ribosomal pocketSemantic proximity Read

Global ribosome profiling reveals that mutant huntingtin stalls ribosomes and represses protein synthesis independent of fragile X mental retardation proteinSemantic proximity Read

RNA degradation analysis reveals ribosome dynamics in complex microbiome samplesSemantic proximity Read

Translational buffering by ribosome stalling in upstream open reading framesSemantic proximity Read

Cotranslational response to proteotoxic stress by elongation pausing of ribosomes.Semantic proximity Read

Specific recognition and ubiquitination of slow-moving ribosomes by human CCR4-NOTSemantic proximity Read

Disome and Trisome Profiling Reveal Genome-wide Targets of Ribosome Quality Control.Semantic proximity Read

SPARP-seq reveals poly(A) tail shortening as a hallmark of the active human translatomeSemantic proximity Read

Translational buffering tunes gene expression in mice and humansSemantic proximity Read

Protein Synthesis Profiling Enables In Vivo Capture of Ribosome-Associated mRNAs in YeastSemantic proximity Read

Quality control ensures fidelity in ribosome assembly and cellular healthSemantic proximity Read