Article
Translation arrest requires two-way communication between a nascent polypeptide and the ribosome.
Molecular cell - 9 Jun 2006
Woolhead Cheryl A, Johnson Arthur E, Bernstein Harris D
Abstract excerpt
When the export of E. coli SecM is blocked, a 17 amino acid motif near the C terminus of the protein induces a translation arrest from within the ribosome tunnel. Here we used a recently described application of fluorescence resonance energy transfer (FRET) to gain insight into the mechanism of translation arrest. We found that the SecM C terminus adopted a compact conformation upon synthesis of the arrest motif....
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