Article

Structural basis for context-specific inhibition of translation by oxazolidinone antibiotics

2021-08-10

Abstract excerpt

<h4>ABSTRACT</h4> The antibiotic linezolid, the first clinically approved member of the oxazolidinone class, inhibits translation of bacterial ribosomes by binding to the peptidyl transferase center. Recent work has demonstrated that linezolid does not inhibit peptide bond formation at all sequences but rather acts in a context-specific manner, namely when alanine occupies the penultimate position of the nascent...

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Literature Corpus work: 4dfbc294-d51d-5689-a0d1-0d76109e9a10
DOI: 10.1101/2021.08.10.455846

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