Article
Effects on translation pausing of alterations in protein and RNA components of the ribosome exit tunnel.
Journal of bacteriology - 1 Sept 2008
Lawrence Marlon G, Lindahl Lasse, Zengel Janice M
Abstract excerpt
Amino acids are polymerized into peptides in the peptidyl transferase center of the ribosome. The nascent peptides then pass through the exit tunnel before they reach the extraribosomal environment. A number of nascent peptides interact with the exit tunnel and stall elongation at specific sites within their peptide chain. Several mutational changes in RNA and protein components of the ribosome have previously...
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