Article

Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule

2018-05-05

Abstract excerpt

Small molecules that target the ribosome generally have a global impact on protein synthesis. However, the drug-like molecule PF-06446846 (PF846) binds the human ribosome and selectively blocks the translation of a small subset of proteins by an unknown mechanism. In high-resolution cryo-electron microscopy (cryo-EM) structures of human ribosome nascent chain complexes stalled by PF846, PF846 binds in the ribosome...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ca730536-6799-583e-ad6c-7d633584f6df
DOI: 10.1101/315325

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like moleculeDOI 10.1101/315325Read

Selective inhibition of human translation by a drug-like compound that traps terminated protein nascent chains on the ribosomeSemantic proximity Read

Selective inhibition of human translation termination by a drug-like compound.Semantic proximity Read

Structure–function insights reveal the human ribosome as a cancer target for antibioticsSemantic proximity Read

Conformational diversity of collided ribosomes determines stress signalingSemantic proximity Read

Deep conservation of ribosome stall sites across RNA processing genesSemantic proximity Read

Specific recognition and ubiquitination of slow-moving ribosomes by human CCR4-NOTSemantic proximity Read

Characterization of a potential antibiotic target site on the ribosomeSemantic proximity Read

SARS-CoV-2 Nsp1 binds the ribosomal mRNA channel to inhibit translation.Semantic proximity Read

Structural and mechanistic basis for translation inhibition by macrolide and ketolide antibioticsSemantic proximity Read

Context-specific action of macrolide antibiotics on the eukaryotic ribosome.Semantic proximity Read

Genome-wide Survey of Ribosome CollisionSemantic proximity Read

Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetineSemantic proximity Read