The CYP3A5 genotypes of both liver transplant recipients and donors influence the time‐dependent recovery of tacrolimus clearance during the early stage following transplantation

Abstract excerpt

The majority of allograft rejection occurs within 1 month after liver transplantation; with the highest incidence around 7–10 days. In this study, we demonstrate the impact of donor and recipient genotypes on tacrolimus clearance and dosing requirements during the first 28 days following liver transplantation. Tacrolimus is primarily metabolized by cytochrome P450 (CYP) 3A isozymes, CYP3A4 and CYP3A5, which...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Organ Transplantation Techniques and Outcomes
• Share to Pharmacological Effects and Toxicity Studies