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Impact of genetic polymorphisms on tacrolimus trough blood concentration in Chinese liver transplant recipients.

Pharmacogenomics - 1 Mar 2023

Maseko Nicola, Yang Siyao, Li Chengcheng, Zhang Siqi, Wang Ruiying, Zhang Yawen, Li Chuanjiang, Zhang Chuanjie, Li Liang

Abstract excerpt

Purpose: The aim of this study was to analyze the effects of various genetic polymorphisms and clinical factors on tacrolimus (TAC) concentration in the convalescence period (CP) and stabilization period (SP) post-liver transplantation. Patients & methods: A total of 13 SNPs were genotyped in 97 Chinese liver transplant recipients. Associations between SNPs and TAC trough blood concentration/dose ratio (C0/D)...

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Identifiers

PMID: 36927114
DOI: 10.2217/pgs-2022-0180

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