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Pharmacokinetic and CYP3A5 pharmacogenetic differences between once- and twice-daily tacrolimus from the first dosing day to 1 year after renal transplantation.

Pharmacogenomics - 1 Aug 2014

Satoh Shigeru, Niioka Takenori, Kagaya Hideaki, Numakura Kazuyuki, Inoue Takamitsu, Saito Mitsuru, Komine Naoki, Narita Shintaro, Tsuchiya Norihiko, Habuchi Tomonori, Miura Masatomo

Abstract excerpt

UNLABELLED: Aim & patients & methods: This study investigated 24-h pharmacokinetic and CYP3A5 pharmacogenetic differences between once-daily tacrolimus (Tac-q.d.) versus twice-daily tacrolimus (Tac-b.i.d.) pretransplantation and at 1 month and 1 year post-transplantaion. RESULTS: The dose-adjusted trough level (Cmin) and area under the blood concentration-time curve from 0 to 24 h (AUC₀₋₂₄) increased twofold...

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Identifiers

PMID: 25303300
DOI: 10.2217/pgs.14.98

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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