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Article

Cancer-associated mutations in the iron-sulfur domain of FANCJ affect G-quadruplex metabolism.

PLoS genetics - 1 Jun 2020

Odermatt Diana C, Lee Wei Ting C, Wild Sebastian, Jozwiakowski Stanislaw K, Rothenberg Eli, Gari Kerstin

Abstract excerpt

FANCJ/BRIP1 is an iron-sulfur (FeS) cluster-binding DNA helicase involved in DNA inter-strand cross-link (ICL) repair and G-quadruplex (G4) metabolism. Mutations in FANCJ are associated with Fanconi anemia and an increased risk for developing breast and ovarian cancer. Several cancer-associated mutations are located in the FeS domain of FANCJ, but how they affect FeS cluster binding and/or FANCJ activity has...

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PMID: 32542039
DOI: 10.1371/journal.pgen.1008740
PMCID: PMC7316351

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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