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Article

FANCJ is a structure-specific DNA helicase associated with the maintenance of genomic G/C tracts.

The Journal of biological chemistry - 26 Dec 2008

London Timothy B C, Barber Louise J, Mosedale Georgina, Kelly Gavin P, Balasubramanian Shankar, Hickson Ian D, Boulton Simon J, Hiom Kevin

Abstract excerpt

Fanconi anemia (FA) is a heritable human cancer-susceptibility disorder, delineating a genetically heterogenous pathway for the repair of replication-blocking lesions such as interstrand DNA cross-links. Here we demonstrate that one component of this pathway, FANCJ, is a structure-specific DNA helicase that dissociates guanine quadruplex DNA (G4 DNA) in vitro. Moreover, in contrast with previously identified G4...

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Identifiers

PMID: 18978354
DOI: 10.1074/jbc.M808152200
PMCID: PMC2662291

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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