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Article

FANCJ suppresses microsatellite instability and lymphomagenesis independent of the Fanconi anemia pathway.

Genes & development - 15 Dec 2015

Matsuzaki Kenichiro, Borel Valerie, Adelman Carrie A, Schindler Detlev, Boulton Simon J

Abstract excerpt

Microsatellites are short tandem repeat sequences that are highly prone to expansion/contraction due to their propensity to form non-B-form DNA structures, which hinder DNA polymerases and provoke template slippage. Although error correction by mismatch repair plays a key role in preventing microsatellite instability (MSI), which is a hallmark of Lynch syndrome, activities must also exist that unwind secondary...

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PMID: 26637282
DOI: 10.1101/gad.272740.115
PMCID: PMC4699383

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