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Article

DOG-1 is the Caenorhabditis elegans BRIP1/FANCJ homologue and functions in interstrand cross-link repair.

Molecular and cellular biology - 1 Mar 2008

Youds Jillian L, Barber Louise J, Ward Jordan D, Collis Spencer J, O'Neil Nigel J, Boulton Simon J, Rose Ann M

Abstract excerpt

Fanconi anemia (FA) is a cancer susceptibility syndrome characterized by defective DNA interstrand cross-link (ICL) repair. Here, we show that DOG-1 is the Caenorhabditis elegans homologue of FANCJ, a helicase mutated in FA-J patients. DOG-1 performs a conserved role in ICL repair, as dog-1 mutants are hypersensitive to ICL-inducing agents, but not to UVC irradiation or X rays. Genetic analysis indicated that...

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Source

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Identifiers

PMID: 18086896
DOI: 10.1128/MCB.01641-07
PMCID: PMC2258786

Genes

BRCA1
BRIP1
FANCD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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DOG-1 is the Caenorhabditis elegans BRIP1/FANCJ homologue and functions in interstrand cross-link repair.PMID 18086896Read ↗

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