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The FANC/BRCA Pathway Releases Replication Blockades by Eliminating DNA Interstrand Cross-Links

25 May 2020

Abstract excerpt

DNA interstrand cross-links (ICLs) represent a major barrier blocking DNA replication fork progression. ICL accumulation results in growth arrest and cell death-particularly in cell populations undergoing high replicative activity, such as cancer and leukemic cells. For this reason, agents able to induce DNA ICLs are widely used as chemotherapeutic drugs. However, ICLs are also generated in cells as byproducts of...

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PMID: 32466131
DOI: 10.3390/genes11050585

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