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Article

Gcn4 is required for the response to peroxide stress in the yeast Saccharomyces cerevisiae.

Molecular biology of the cell - 1 Jul 2008

Mascarenhas Claire, Edwards-Ingram Laura C, Zeef Leo, Shenton Daniel, Ashe Mark P, Grant Chris M

Abstract excerpt

An oxidative stress occurs when reactive oxygen species overwhelm the cellular antioxidant defenses. We have examined the regulation of protein synthesis in Saccharomyces cerevisiae in response to oxidative stress induced by exposure to hydroperoxides (hydrogen peroxide, and cumene hydroperoxide), a thiol oxidant (diamide), and a heavy metal (cadmium). Examination of translational activity indicates that these...

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Identifiers

PMID: 18417611
DOI: 10.1091/mbc.e07-11-1173
PMCID: PMC2441660

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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