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Article

An integrated stress response regulates amino acid metabolism and resistance to oxidative stress.

Molecular cell - 1 Mar 2003

Harding Heather P, Zhang Yuhong, Zeng Huiquing, Novoa Isabel, Lu Phoebe D, Calfon Marcella, Sadri Navid, Yun Chi, Popko Brian, Paules Richard, Stojdl David F, Bell John C, Hettmann Thore, Leiden Jeffrey M, Ron David

Abstract excerpt

Eukaryotic cells respond to unfolded proteins in their endoplasmic reticulum (ER stress), amino acid starvation, or oxidants by phosphorylating the alpha subunit of translation initiation factor 2 (eIF2alpha). This adaptation inhibits general protein synthesis while promoting translation and expression of the transcription factor ATF4. Atf4(-/-) cells are impaired in expressing genes involved in amino acid...

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Source

Identifiers

PMID: 12667446
DOI: 10.1016/s1097-2765(03)00105-9

Genes

ATF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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