Article

Thiol reductive stress activates the hypoxia response pathway

2023-03-06

Abstract excerpt

Owing to their capability to disrupt the oxidative protein folding environment in the endoplasmic reticulum (ER), thiol antioxidants such as dithiothreitol (DTT) are used as ER-specific stressors. We recently showed that thiol antioxidants modulate the methionine-homocysteine cycle by upregulating an S-adenosylmethionine-dependent methyltransferase, rips-1 , in Caenorhabditis elegans . However, the changes in ce...

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Literature Corpus work: 1a242405-8b6f-5a19-83b2-e6106d414e0c
DOI: 10.1101/2023.03.06.531274

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