Article
CIA2 deficiency results in impaired oxidative stress response and enhanced intracellular basal UPR activity in Saccharomyces cerevisiae.
FEMS microbiology letters - 1 Mar 2015
Zhao Wei, Zheng Hua-Zhen, Niu Yu-Jie, Yuan Yuan, Fang Bing-Xiong, Liu Yi-Na, Cai Lu-Hui, Zhou Zhong-Jun, Liu Xin-Guang
Abstract excerpt
Yeast Cia2p is a component of the cytosolic Fe/S protein assembly (CIA) machinery. Initial studies of the CIA machinery were performed in yeast, but the precise role of Cia2p in this eukaryote is still unknown. We report that CIA2 deficiency results in impaired oxidative stress response, as evidenced by increased sensitivity to the oxidant cumene hydroperoxide (CHP), impaired activities of superoxide dismutases...
Topics
- Basic-Leucine Zipper Transcription Factors
- Benzene Derivatives
- Cytoplasm
- Endoplasmic Reticulum Stress
- Mutation
- Oxidative Stress
- Reactive Oxygen Species
- Real-Time Polymerase Chain Reaction
- Repressor Proteins
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Signal Transduction