Article
Thiol peroxidases mediate specific genome-wide regulation of gene expression in response to hydrogen peroxide.
Proceedings of the National Academy of Sciences of the United States of America - 15 Feb 2011
Fomenko Dmitri E, Koc Ahmet, Agisheva Natalia, Jacobsen Michael, Kaya Alaattin, Malinouski Mikalai, Rutherford Julian C, Siu Kam-Leung, Jin Dong-Yan, Winge Dennis R, Gladyshev Vadim N
Abstract excerpt
Hydrogen peroxide is thought to regulate cellular processes by direct oxidation of numerous cellular proteins, whereas antioxidants, most notably thiol peroxidases, are thought to reduce peroxides and inhibit H(2)O(2) response. However, thiol peroxidases have also been implicated in activation of transcription factors and signaling. It remains unclear if these enzymes stimulate or inhibit redox regulation and...
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