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Article

Impact of phosphorylation and phosphorylation-null mutants on the activity and deamination specificity of activation-induced cytidine deaminase.

The Journal of biological chemistry - 20 Jun 2008

Pham Phuong, Smolka Marcus B, Calabrese Peter, Landolph Alice, Zhang Ke, Zhou Huilin, Goodman Myron F

Abstract excerpt

Activation-induced cytidine deaminase (AID) initiates somatic hypermutation and class switch recombination in B cells by deaminating C --> U on transcribed DNA. Here we analyze the role of phosphorylation and phosphorylation-null mutants on the biochemical behavior of AID, including enzyme specific activity, processivity, deamination spectra, deamination motif specificity, and transcription-dependent deamination...

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Source

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Identifiers

PMID: 18417471
DOI: 10.1074/jbc.M802121200
PMCID: PMC2427360

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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