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Article

Regulation of activation-induced cytidine deaminase DNA deamination activity in B-cells by Ser38 phosphorylation.

Biochemical Society transactions - 1 Jun 2009

Basu Uttiya, Franklin Andrew, Schwer Bjoern, Cheng Hwei-Ling, Chaudhuri Jayanta, Alt Frederick W

Abstract excerpt

Human and mouse Ig genes are diversified in mature B-cells by distinct processes known as Ig heavy-chain CSR (class switch recombination) and Ig variable-region exon SHM (somatic hypermutation). These DNA-modification processes are initiated by AID (activation-induced cytidine deaminase), a DNA cytidine deaminase predominantly expressed in activated B-cells. AID is post-transcriptionally regulated via multiple...

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Identifiers

PMID: 19442251
DOI: 10.1042/BST0370561
PMCID: PMC3540414

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Regulation of activation-induced cytidine deaminase DNA deamination activity in B-cells by Ser38 phosphorylation.PMID 19442251Read ↗

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