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Article

Integrity of the AID serine-38 phosphorylation site is critical for class switch recombination and somatic hypermutation in mice.

Proceedings of the National Academy of Sciences of the United States of America - 24 Feb 2009

Cheng Hwei-Ling, Vuong Bao Q, Basu Uttiya, Franklin Andrew, Schwer Bjoern, Astarita Jillian, Phan Ryan T, Datta Abhishek, Manis John, Alt Frederick W, Chaudhuri Jayanta

Abstract excerpt

Activation-induced cytidine deaminase (AID) is a single-stranded (ss) DNA-specific cytidine deaminase that initiates Ig heavy chain (IgH) class switch recombination (CSR) and Ig somatic hypermutation (SHM) by deaminating cytidines within, respectively, IgH switch (S) regions and Ig variable regio...

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Identifiers

PMID: 19196992
DOI: 10.1073/pnas.0812304106
PMCID: PMC2650332

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19196992-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Integrity of the AID serine-38 phosphorylation site is critical for class switch recombination and somatic hypermutation in mice.PMID 19196992Read ↗

Regulation of activation-induced cytidine deaminase DNA deamination activity in B-cells by Ser38 phosphorylation.Semantic proximity Read ↗

Impact of phosphorylation and phosphorylation-null mutants on the activity and deamination specificity of activation-induced cytidine deaminase.Semantic proximity Read ↗

AID- and Ung-dependent generation of staggered double-strand DNA breaks in immunoglobulin class switch DNA recombination: a post-cleavage role for AID.Semantic proximity Read ↗

A Hyper-IgM Syndrome Mutation in Activation-Induced Cytidine Deaminase Disrupts G-Quadruplex Binding and Genome-wide Chromatin Localization.Semantic proximity Read ↗

The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation.Semantic proximity Read ↗

Depletion of recombination-specific cofactors by the C-terminal mutant of the activation-induced cytidine deaminase causes the dominant negative effect on class switch recombination.Semantic proximity Read ↗

Phosphorylation promotes activation-induced cytidine deaminase activity at the Myc oncogene.Semantic proximity Read ↗

Haploinsufficiency of Activation-Induced Deaminase for Antibody Diversification and Chromosome Translocations both In Vitro and In VivoSemantic proximity Read ↗

Epigenetic targeting of activation-induced cytidine deaminaseSemantic proximity Read ↗

Separate domains of AID are required for somatic hypermutation and class-switch recombination.Semantic proximity Read ↗

C-terminal deletion of AID uncouples class switch recombination from somatic hypermutation and gene conversion.Semantic proximity Read ↗

Regulation of AID expression in the immune responseSemantic proximity Read ↗

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