Article
APOE epsilon 4 lowers age at onset and is a high risk factor for Alzheimer's disease; a case control study from central Norway.
BMC neurology - 16 Apr 2008
Sando Sigrid B, Melquist Stacey, Cannon Ashley, Hutton Michael L, Sletvold Olav, Saltvedt Ingvild, White Linda R, Lydersen Stian, Aasly Jan O
Abstract excerpt
BACKGROUND: The objective of this study was to analyze factors influencing the risk and timing of Alzheimer's disease (AD) in central Norway. The APOE epsilon4 allele is the only consistently identified risk factor for late onset Alzheimer's disease (LOAD). We have described the allele frequencies of the apolipoprotein E gene (APOE) in a large population of patients with AD compared to the frequencies in a...
Topics
- Age of Onset
- Aged
- Aged, 80 and over
- Alleles
- Alzheimer Disease
- Apolipoprotein E4
- Case-Control Studies
- Female
- Gene Frequency
- Humans
- Male