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Article

Most rapid cognitive decline in APOE epsilon4 negative Alzheimer's disease with early onset.

Psychological medicine - 1 Nov 2009

van der Vlies A E, Koedam E L G E, Pijnenburg Y A L, Twisk J W R, Scheltens P, van der Flier W M

Abstract excerpt

BACKGROUND: We aimed to compare the rate of cognitive decline in patients with early and late onset Alzheimer's disease (AD) and to investigate the potentially modifying influence of the apolipoprotein E (APOE) genotype. METHOD: We included 99 patients with early onset AD (age 65 years) and 192 patients with late onset AD (age >65 years) who had at least two scores on the Mini-Mental State Examination (MMSE)...

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Source

Identifiers

PMID: 19335933
DOI: 10.1017/S0033291709005492

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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